Senior Clinical Research Manager

• Job Type: Officer of Administration
• Bargaining Unit:
• Regular/Temporary: Regular
• End Date if Temporary:
• Hours Per Week: 35
• Standard Work Schedule:
• Building:
• Salary Range: $115,000 - $125,000

Position Summary

The Senior Clinical Research Manager (Sr. CRM) is a key member of the CPDM leadership team, responsible for overseeing clinical research operations, portfolio strategy, and staff management. This role expands upon the Clinical Research Manager (CRM) position by incorporating higher-level leadership, strategic planning, financial oversight, and departmental initiatives. The Sr. CRM ensures efficient trial execution, regulatory compliance, financial sustainability, and staff development while supporting institutional and NCI priorities. The Senior Clinical Research Manager reports to the Assistant Director, Clinical Research Operations and is primarily based out of 161 Fort Washington Avenue, New York, NY.

Subject to business needs, we may support flexible and hybrid work arrangements. Options will be discussed during the interview process.

Responsibilities

Leadership & Staffing

• Lead workforce planning, including justification, recruitment, and hiring of staff
• Oversee onboarding, training, and professional development programs across roles (CRMs, CRCs, DCs, etc.)
• Conduct performance evaluations, set goals, and support career progression pathway
• Provide mentorship and leadership development programs for managers and senior coordinators
• Partner with HR on workforce compliance and staffing strategies

Supervision & Operational Oversight

• Direct and supervise clinical research teams to ensure efficient operations and high-quality output
• Oversee workload distribution, protocol assignments, and resource allocation based on trial complexity
• Ensure timely, accurate data collection, entry, and reporting
• Implement and monitor quality control systems for:
  
  • Data integrity
  • Clinical trial billing compliance
  • Patient recruitment and retention
• Ensure team readiness for audits, monitoring visits, and regulatory inspections
• Provide escalation support and resolution for operational challenges

Protocol & Portfolio Management

• Lead portfolio strategy, including feasibility assessments, prioritization, and pipeline development
• Oversee study lifecycle: start-up, activation, accrual, maintenance, and close-out
• Evaluate trial performance (accrual, complexity, resource utilization) and adjust strategy accordingly
• Collaborate with investigators and multidisciplinary teams to ensure operational feasibility
• Represent CPDM in disease team meetings and institutional forums
• Support investigator-initiated trials including CRF development and implementation 

Financial Management

• Oversee study budget development, negotiation, and lifecycle financial management
• Monitor financial performance across trials and identify variances and risks
• Collaborate with leadership to implement corrective actions and optimize resource utilization
• Ensure alignment with institutional financial goals and sustainability

Departmental & Strategic Initiatives

• Lead development and implementation of SOPs and operational best practice
• Drive process improvements to enhance efficiency, compliance, and staff experience
• Develop standardized tools, templates, and workflows across CPDM
• Lead or contribute to cross-functional and institutional projects
• Support staff engagement, retention, and cross-coverage models 

External Relations & Compliance

• Serve as primary liaison for:
  • Sponsors
  • External audits
• Support development of industry and academic partnerships
• Ensure compliance with ICH-GCP, CFR, and institutional policies

Other Duties

• Perform additional responsibilities as assigned in support of departmental and institutional goals

Minimum Qualifications

• Bachelor's degree or equivalent in education and experience required and 4 years related experience.

Preferred Qualifications

• At least 2 years of Oncology Clinical trials experience and 2 years of Oncology Clinical trials managerial experience.
• SOCRA or equivalent certification.
• Excellent interpersonal and organizational skills.
• Computer Skills: proficiency with MS Word programs and familiarity with Mac and PC platforms.
• Master’s degree in management or public health is preferable.

Equal Opportunity Employer / Disability / Veteran

Columbia University is committed to the hiring of qualified local residents.