• Job Type: Support Staff - Union
• Bargaining Unit: SSA
• Regular/Temporary: Regular
• End Date if Temporary:
• Hours Per Week: 35
• Standard Work Schedule:
• Building:
• Salary Range: $51,839 - $51,839

Position Summary

Dr. Chaolin Zhang’s laboratory at the Columbia University Irving Medical Center is seeking a highly motivated Technician B to support ongoing research projects in the lab.

Located in the Hammer building, the Zhang Laboratory is part of Department of Systems Biology, Department of Biochemistry and Molecular Biophysics (BMB), and the Center for Motor Neuron Biology and Disease (MNC). Our efforts are primarily to understand the broad roles that co-, and post-transcriptional regulatory processes (such as alternative pre-mRNA splicing) play during neurodevelopment and in the course of incurable neurodegenerative diseases, and to exploit RNA biogenesis as novel targets for therapeutics. The lab employs stem-cell-derived neuronal cultures, brain organoids and in vivo mouse models using a combination of biochemistry, molecular biology, and high-throughput quantitative and integrative approaches.

Responsibilities

• Overall, the Technician B will have dynamic responsibilities within a highly collaborative environment to yield fundamental biological insights about the nervous system and to develop novel stem-cell-based biotechnologies for neurological disease. Ideal candidates are those interested in using state-of-the-art techniques to generate a variety of neurons from stem cells carrying pathogenic mutations, to explore mechanisms of disease in the dish by conducting perturbation screens, and to investigate potential oligonucleotide drugs in this context.

• Successful applicants will join a vibrant, interdisciplinary and productive research team, with continuous opportunities for technical and intellectual growth. They will work closely with the principal investigator, post docs, and graduate students in designing, carrying out, and coordinating research. More information about the Zhang laboratory can be found at http://zhanglab.c2b2.columbia.edu.

Minimum Qualifications

• Bachelor’s degree in a biological science or related subject area, or an equivalent combination of relevant education and experience.
• Experience working with stem cells, neuronal differentiations, and cell biology assays, such as immunostainings and imaging.
• Familiar with standard molecular biology techniques, such as cloning, DNA/RNA/protein extraction, electrophoresis, immunoblotting, etc.
• Great organizational and time management skills.
• Excellent writing and communication skills, and a passion to work in a team environment.

Preferred Qualifications

• Master’s degree in a biological science or related subject area.
• Background in neurobiology.
• Vivarium experience, including basic mouse handling and husbandry, breeding and genotyping procedures.

Equal Opportunity Employer / Disability / Veteran

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